Process Development & Scale-Up
Capot provides process development and scale-up support for complex chemistry projects, covering route evaluation, reaction optimisation, impurity control, process robustness, scale-up verification and technology transfer, helping customers progressively convert laboratory processes into repeatable, scalable manufacturing.
Explore our process development capabilities →Process Development Capabilities
Route Evaluation & Optimisation
Synthetic route evaluation and optimisation considering raw material availability, safety, cost, yield and scalability.
Reaction Optimisation
Optimisation of reaction parameters to improve conversion, selectivity, yield and process repeatability.
Impurity Control
Identification and control of process-related impurities through route, reaction and purification optimisation.
Purification & Separation
Development of crystallisation, extraction, filtration and separation processes suitable for scale-up.
Process Robustness
Evaluation of critical process parameters and operating ranges to improve consistency and manufacturability.
Technology Transfer
Preparation of process documentation and support for transfer from R&D to pilot and production stages.
From Process Development to Scale
01 Laboratory Assessment
Evaluate existing chemistry routes, process risks, critical parameters and development requirements.
02 Process Optimisation
Optimise reaction conditions, yield, selectivity, purification methods and process efficiency.
03 Robustness Verification
Verify critical process parameters and operating ranges to improve process repeatability.
04 Pilot Scale-Up
Validate the developed process under larger-scale conditions.
05 Technology Transfer & Production
Transfer process knowledge and technical requirements into the production stage.
Process Development Priorities
Key Scale-Up Considerations
Mixing & Mass Transfer
Assess how mixing efficiency and mass-transfer behaviour change during scale-up.
Heat Transfer Control
Evaluate reaction heat and temperature control requirements under scale-up conditions.
Dosing Strategy
Optimise addition sequence and rate to improve reaction control and consistency.
Work-Up & Separation
Scale-up assessment of extraction, filtration, crystallisation, washing and drying operations.
Process Safety & Controlled Scale-Up
Process safety is integrated throughout development and scale-up. Before transferring to larger equipment, Capot evaluates reaction behaviour, thermal characteristics, operating conditions and scale-up-related risks as required by the project.
Chemistry & Process Technologies →Project Management
Development Plan
Define development objectives, project milestones and scale-up requirements.
Technical Communication
Maintain continuous technical communication throughout process development and scale-up.
Technical Documentation
Prepare process documentation and development records to support technology transfer and production.
Ready to advance process scale-up?
Share your existing route, project stage and scale-up requirements with us. The Capot team will evaluate the process and discuss an appropriate development and scale-up approach.
Discuss your process project →